HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Reduced incidence of ischemic stroke in patients with severe factor XI deficiency
نویسندگان
چکیده
1The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; 2Department of Statistics and Operations Research, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv; 3Division of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; and 4Stroke Unit, Department of Neurology, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
منابع مشابه
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
Formation of fibrin is critical for limiting blood loss at a site of blood vessel injury (hemostasis), but may also contribute to vascular thrombosis. Hereditary deficiency of factor XII (FXII), the protease that triggers the intrinsic pathway of coagulation in vitro, is not associated with spontaneous or excessive injury-related bleeding, indicating FXII is not required for hemostasis. We demo...
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Factor XI deficiency, an injury-related bleeding disorder, is rare worldwide but common in Jews in whom 2 mutations, Glu117Stop (type II) and Phe283Leu (type III), prevail. Mean factor XI activities in homozygotes for Glu117Stop and for Phe283Leu are 1 and 10 U/dL, respectively. Inhibitors to factor XI in patients with severe factor XI deficiency have been reported in a small number of instance...
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Introduction: Elevated hematocrit is associated with high blood viscosity and could lead to vascular thrombosis. The purpose of this study is to compare hematocit of ischemic stroke and myocardial infarction patients. Methods: All of the patients with ischemic stroke and myocardial infarction (MI) admitted in Vali-e-asr Hospital, Khorasan during 2002-2003 enrolled in this descriptive analytic...
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T he finding that humans with hereditary factor XI deficiency have relatively mild bleeding tendencies—yet are significantly protected against certain thrombotic diseases— has sparked considerable interest in factor XI/XIa as a target for novel antithrombotic treatments. In the classic waterfall description of blood coagulation, there are 2 ways to trigger the plasma clotting system: the tissue...
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